Study on the mechanism of Zhimu in the treatment of ovarian cancer based on network pharmacology

We aimed to investigate the mechanism of action Zhimu in treatment ovarian cancer (OC) using network pharmacology. OC targets were screened DisGeNET and Online Mendelian Inheritance Man databases. Common identified Traditional Chinese Medicine System Pharmacology, UniProt databases, Venny 2.1.0. The protein-protein interaction (PPI) Search Tool for Retrieval Interacting Genes/Proteins database was created Zhimu/OC a active ingredient-target-pathway Cytoscape 3.9.1 software. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analysis conducted Metascape database. And overall, 15 ingredients addition 93 related identified. PPI had 52 that overlapped with it, 10 most relevant being tumour protein p53, necrosis factor, serine/threonine kinase 1, vascular endothelial growth factor A, caspase-3, prostaglandin G/H synthase-2, hypoxia-inducible factor-1 alpha, interleukin-1 beta, heat-shock 90-alpha, progesterone receptor. According GO KEGG analyses, nuclear NF-kappaB signalling pathway, oxidative stress, advanced glycation end product (AGE)/the receptor (RAGE) as common targets. This study highlighted potential molecular therapeutic mechanisms OC. It also provided suggestions directions future research into mechanisms.